ReproStamp

ReproStamp is a web app (with optional CLI) that captures, validates, and “seals” the exact computational context behind a genomics result: pipeline version, parameters, reference genome build, annotation sources, container digest, and input file checksums. It generates a compact, human-readable report plus a machine-verifiable manifest that can be attached to publications, clinical validations, or internal QC sign-off. The app integrates with common workflow engines (Nextflow/WDL/CWL) and major storage locations (S3/GCS/on-prem). It won’t magically fix bad science; it reduces the very real, expensive problem of results that can’t be reproduced months later due to silent changes in references, containers, or parameters. An AI assistant can help detect “drift” (e.g., mismatched GRCh builds, outdated annotation databases) and suggest remediation steps, but the core value is deterministic provenance and audit trails.